Genetic Engineering Will Change Everything Forever - CRISPR

  • Published on Aug 10, 2016
  • Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. The only thing we know for sure is that things will change irreversibly.
    Support us on Patreon so we can make more videos (and get cool stuff in return):
    Kurzgesagt merch here:
    Get the music of the video here:

    Thanks to Volker Henn, James Gurney and (prefers anonymity) for help with this video!
    Jeffrey Schneider, Konstantin Kaganovich, Tom Leiser, Archie Castillo, Russell Eishard, Ben Kershaw, Marius Stollen, Henry Bowman, Ben Johns, Bogdan Radu, Sam Toland, Pierre Thalamy, Christopher Morgan, Rocks Arent People, Ross Devereux, Pascal Michaud, Derek DuBreuil, Sofia Quintero, Robert Swiniarski, Merkt Kızılırmak, Michelle Rowley, Andy Dong, Saphir Patel, Harris Rotto, Thomas Huzij, Ryan James Burke, NTRX, Chaz Lewis, Amir Resali, The War on Stupid, John Pestana, Lucien Delbert, iaDRM, Jacob Edwards, Lauritz Klaus, Jason Hunt, Marcus : ), Taylor Lau, Rhett H Eisenberg, Mr.Z, Jeremy Dumet, Fatman13, Kasturi Raghavan, Kousora, Rich Sekmistrz, Mozart Peter, Gaby Germanos, Andreas Hertle, Alena Vlachova, Zdravko Šašek
    The best book we read about the topic: GMO Sapiens
    (affiliate link, we get a cut if buy the book!)

    - Good Overview by Wired:
    -timeline of computer development:
    - Selective breeding:
    - DNA:
    - Radiation research:
    - inserting DNA snippets into organisms:
    - First genetically modified animal:
    - First GM patent:
    - chemicals produced by GMOs:
    - Flavr Savr Tomato:
    - First Human Engineering:
    - glowing fish:
    - CRISPR:
    - HIV cut from cells and rats with CRISPR:
    - first human CRISPR trials fighting cancer:
    first human CRISPR trial approved by Chinese for August 2016:
    - genetic diseases:
    - pregnancies with Down Syndrome terminated:
    ( 1999 European study)
    - CRISPR and aging:
    Help us caption & translate this video!

Comments • 55 385

  • Kurzgesagt – In a Nutshell

    There's brand new stuff in the Kurzgesagt Merch Shop. Check it out here:

      UNIVERSE 3D 6 days ago +1

      Nice your the best science youtuber

    • Leon Dorrenberg
      Leon Dorrenberg 20 days ago +1

      Please make a video about homosexuality

    • Fire Of Game
      Fire Of Game 27 days ago +2

      I want this amazing genetic engineering in my whole life
      If any bade want to be experiment with me
      Because I know the future is bright in genetic engineering
      I want to live forever

    • Cadence James
      Cadence James 27 days ago +1

      Kurzgesagt - In a Nutshell
      We need a french kurzgesagt, please.

  • Fuser
    Fuser 11 minutes ago


  • Mastered Ultra WrongThink

    Instructions unclear, my son is now Voldemort

  • Ice Tee
    Ice Tee 4 hours ago

    I think we should NOT engineer humans

  • Andrew kerr
    Andrew kerr 5 hours ago

    This is what hitler wanted

  • hank fontaine
    hank fontaine 6 hours ago

    666 sick sick sick the Devils in the music & the lime is in the tick

  • hank fontaine
    hank fontaine 6 hours ago

    Why is it the smarter man gets the more disease there is

  • HyScript7
    HyScript7 9 hours ago

    Is living forever Good or bad?

  • zander allan
    zander allan 11 hours ago

    The reason we die is so that There is no To many people

  • Azure Vox
    Azure Vox 18 hours ago

    Turns out Hitler will get his dream in the end. We all know everyone, even non-white people are going to want their kids to have blue eyes and blonde hair!

    Not complaining, blonde girls are cute!

  • The Emerald Mage
    The Emerald Mage 19 hours ago


  • Dog Lady
    Dog Lady Day ago

    This treatment will never be approved for anything because it’s not profitable and unfortunately that’s what everything is always about.

  • Bharat Kaushal
    Bharat Kaushal Day ago

    I think CAS9 is cute

  • Jayce Segler
    Jayce Segler Day ago

    Software and Genetic Engineers

  • AcautCandii
    AcautCandii Day ago

    Nah, let people die

  • La Lumière Huguenote

    Terminate pregnancy. Another expression for killing a human life. "o but we do it ethically". Yea, k.

  • ratbag the weak
    ratbag the weak Day ago

    The thing about trying to eliminate tons of diseases like cancer and the ones that kill lots of people, and trying to almost completely get rid of aging, overpopulation would be one of the biggest problem. Overpopulation is already a big problem right now, but imagine how much of a problem it would be if almost everyone died after 1000 years, and diseases have just been wiped off the table.

  • • McKenna •
    • McKenna • Day ago

    Yeah, but there’s the risk of off-target effects, and I’m not about that. There’s also a chance it doesn’t even work. What’s cool, though, is that there’s a gene drive that ensures the changed genes pass down through generations, which means less editing is needed. But with the off-target effects, Cas9 is led by an RNA guide and scientists don’t know where exactly it will end up, which can caused unexpected mutations. They have computers to predict where the protein ends up, but they can’t really calculate it and it can go anywhere, changing base pairs and the proteins that are made. A test was actually done on mice to cure blindness, which worked, but there were more than 200 unexpected mutations. It’s a fascinating technology, honestly.

  • Adittya Abir Dhrubo

    0:24 adventure duck

  • Aspire D
    Aspire D Day ago +2

    "Its ok to have 4 arms, if everybody has 4 arms" -me
    So yeah, this is why I think that the "warfare" side of this story will be fineee. Besides, what can a super human do vs a nuke?

  • Aspire D
    Aspire D Day ago +1

    9:07 I like the way he says the word "babies".

  • Gijs Groote
    Gijs Groote Day ago

    3:36 rick and mm*otherfuninnggg morthy

  • TreyNitrotoluene
    TreyNitrotoluene 2 days ago +4

    Today we complain about anti-vaxxers, tomorrow its anti-crispers.

  • natty features EVERYTHING

    i m not afraid this brought joyful tears to my eyes sadly this wont be available in time for my aunt who has stage 4 heart cancer.... i might not be able to save her life with it but i m going into this flied and i hope to save as many lives as i can that time and discovery will allow

  • WorldOFwarcraftLIVE
    WorldOFwarcraftLIVE 2 days ago

    herpes cure for the low low price of 200 treatment plans and doctor visits, no need for one shot though just drag it out like we do with chemotherapy

  • AshPlayz- Gaming and more!

    Can you design me a soul, coz I don't have one...

  • Calpeper Minutemen
    Calpeper Minutemen 2 days ago


  • Ben Brooks
    Ben Brooks 2 days ago +4

    Future be like:
    Johnny’s got a bout of pancreatic cancer so he’s staying home today, he should be back to Normal in a few days time!

  • Mihai Budau
    Mihai Budau 2 days ago

    I have poor eyesight but extraordinary intelligence. So, does that mean that i am modified without a lab, if i was born in 2010?

  • J R42
    J R42 2 days ago

    The world is not interested in curing cancer or HIV, because there is so much profit in bad treatments! Still, the question exists, if we were able to cure all diseases, can the Earth cope with more population growth?

  • Karl Jo
    Karl Jo 3 days ago

    hope we can be free of diseases and die in a peaceful sleep

  • Dany Veiga
    Dany Veiga 3 days ago

    well... that escalate quickly

  • Ducky McDuckface
    Ducky McDuckface 3 days ago +2

    Ah bio-ethics, the bane of every bioscientific engineer

  • Kid_Who_Plays _Drums_
    Kid_Who_Plays _Drums_ 3 days ago +2

    Maybe we can make the first real captain America serum but reallly just gene editing

  • Graustreif 06
    Graustreif 06 3 days ago +3

    I will be the first s Scientist in History to create a Fox Furry successful

  • Raghu Seetharaman
    Raghu Seetharaman 3 days ago +7

    At this point, we need a new college major called *Future Engineering* which produces a new profession called *Futuristic Research Scientist/Engineer.*
    They can do research in AI, Transhumanism, Space Travel, Dyson Spheres, Solar Energy Use, etc. They reference science fiction directly as the foundation of inspiration for their research.
    And Kurzgesagt is playing 24/7 at these research institutions.

  • Paradox/Guy
    Paradox/Guy 3 days ago +1

    Very cool, but why I am not glow in the dark?

  • Mohammed Azeem
    Mohammed Azeem 3 days ago

    So we can create customized human ?

  • Blue Lightning Bug
    Blue Lightning Bug 3 days ago

    Imagine a gene edited human that is completely perfect then applying a neural lace

  • Abby Wachter
    Abby Wachter 3 days ago

    i love this video thank you so much

  • Sybyl7 1
    Sybyl7 1 3 days ago

    These bioengineered people will may be born observed of certain desieses but , they will have a inferiority and much shortened life span . One can only look at other species that have been reduced with weakness . Let alone this a serious form of eugenics.

  • Outakantaï Gaming
    Outakantaï Gaming 4 days ago

    Remind Seedship

  • Carlos Betancourt
    Carlos Betancourt 4 days ago +1

    In other words,life is but a dream....

  • Dragón de 8 cabezas

    I want to be a dragon :vvvvvvv

    • Dragón de 8 cabezas
      Dragón de 8 cabezas 4 days ago

      If this happen while i'm still alive i'll be like;
      Plastic Surgeon: so what you wanna change
      Me: um i want like a tail and horns, scaily skin...

  • TUSezRUS
    TUSezRUS 4 days ago


  • BossBabyPlayz
    BossBabyPlayz 4 days ago +1

    12:23 is your marge. like to be pure blood.

  • The Bench
    The Bench 4 days ago

    So it's getting cheap, so 50 yrs in the future someone with a understanding of this tech. could make a bio weapon in a lab in there basement??

  • Minh Khôi Phạm
    Minh Khôi Phạm 4 days ago

    Nếu mọi người đều là siêu nhân thì thế giới sẽ không còn siêu nhân nữa

  • Tom Maitland
    Tom Maitland 4 days ago

    Super human children can robots that take over with cross fire of aliens attacking and the sun exploding, thank you for the movie idea

  • Ryaken
    Ryaken 4 days ago

    Skynet Judgement Day

  • Aamir Hakeem
    Aamir Hakeem 4 days ago

    Rick and Morty 3:34

  • Bethlehem Eisenhour
    Bethlehem Eisenhour 4 days ago

    Designer babies????? Jesus come soon, the world is about to become zombies that worship the devil.

  • Cameron McIntosh
    Cameron McIntosh 4 days ago +1

    if you read this your gay

  • Nytes1982
    Nytes1982 4 days ago

    13:41 Rick is trying to create a perfect Morty aye?

  • Heshan Shibry
    Heshan Shibry 4 days ago

    Great but if it goes to the wrong hands this will be more dangerous to all life everywhere.

  • Princess SaraFina
    Princess SaraFina 4 days ago

    Alright.. This is some Mad Scientist Shit.
    Let's get this going

  • DemonicFlaim1000
    DemonicFlaim1000 4 days ago

    This video is so well done, but I feel like I'll have to watch it a fee times to really understand everything. I feel so dumb.
    Edit: wait, are you telling me that my great great grandchildren will be immortal superheroes!?!?

  • Laura Holmes
    Laura Holmes 4 days ago

    12:00 - always thought merpeople could exist! But I was thinking past, and not imagining future! Cool.

  • Spencer Eaton
    Spencer Eaton 5 days ago

    So why do cancer and HIV still exist? Oh because of capitalism. Curing diseases isn't lucrative in the long run. What could almost immediately change the world for the better will instead be slowly marketed over the next century and only in ways that can make a lot of money.

  • Love To Do Cool Stuff

    Lets do it!

  • Varga Levente
    Varga Levente 5 days ago

    That is just not how humans were made to work it is just unnatural to change someones dna and why would be a parent so primitive to change the way he/she wants their kid to look like i think it should be the kids choice when he/she is older and i am also in hate with gmo (i'm not an ani vaxx mom i'm an 11 year old boy) oh and also eternal youth is just like wtf i mean i know it's trends and stuff to not have those thingies on your face but come one guys srsly
    Just imagine everyone having the same looks amd personalitys now that is a thing that would destroy humanity

  • Brotein Shaketh
    Brotein Shaketh 5 days ago

    Don't fuck with nature faggots

  • Brotein Shaketh
    Brotein Shaketh 5 days ago


  • Astroboys1234
    Astroboys1234 5 days ago +1

    Also, you're telling me that I could have three arms? Kewl.

  • Astroboys1234
    Astroboys1234 5 days ago

    Don't worry. Elon Musk will do it.

  • WheeByulHwaSun
    WheeByulHwaSun 5 days ago +1

    Anti-genetic modification will be the new anti-vaccine.
    Many pros, but some idiot will think the cons will be worse.

    • WheeByulHwaSun
      WheeByulHwaSun Day ago

      • McKenna • vaccine was considered impossible in the past, but look at it now.
      That is what is gonna happen with this.

    • • McKenna •
      • McKenna • Day ago

      Yeah, but there’s the risk of off-target effects, and I’m not about that. There’s also a chance it doesn’t even work. What’s cool, though, is that there’s a gene drive that ensures the changed genes pass down through generations, which means less editing is needed. But with the off-target effects, Cas9 is led by an RNA guide and scientists don’t know where exactly it will end up, which can caused unexpected mutations. They have computers to predict where the protein ends up, but they can’t really calculate it and it can go anywhere, changing base pairs and the proteins that are made. A test was actually done on mice to cure blindness, which worked, but there were more than 200 unexpected mutations. It’s a fascinating technology, honestly. But I also agree that we should cure cancer if we can, it just has to be caught early on. It’s just a huge ethical issue, and there are a ton of risks, but I guess that goes with any gene-editing technology.

    • Dragón de 8 cabezas
      Dragón de 8 cabezas 4 days ago

      stupid people be like: It causes autism i don't wanna cure cancer to my baby.

  • Jason Boisvert
    Jason Boisvert 5 days ago

    Elon Musk, where you at?! 11:27

  • Matheus Lincoln
    Matheus Lincoln 5 days ago

    13:30 ah shit, here we go again...

  • Andrew Erickson
    Andrew Erickson 5 days ago

    Great video! I love how you guys present most sides of it.

  • The duck lord
    The duck lord 5 days ago

    Ya all do relly like advanture time dont you

  • Prajwal Pingali
    Prajwal Pingali 5 days ago

    Did anybody notice cgpgrey bot!

  • The FireSeeker
    The FireSeeker 6 days ago

    10:00 it’s tan af goku

  • Andrew Hynes
    Andrew Hynes 6 days ago +1

    Yo that Rick and Morty animation slipped in there lmao

  • Moto Back to constitution

    Thank you shearing info I whould like to donate when usuful infomation I can use every happens . like activate 12 strend or 4 strend DNA and comunicate with diffarent frequency.

  • Nexo
    Nexo 6 days ago

    Als ob das Orginal Deutsch ist.

  • Rhettorical
    Rhettorical 6 days ago

    Star Trek: Deep Space 9 covered the moral implications of genetic engineering in 1997 in "Statistical Probabilities", and before that, the original series episode "Space Seed". Basically, the rise of genetic modification led to the first genetically-modified superhumans taking over and limiting access to modification to suit their needs, resulting in the "Eugenics Wars" of the 1990s. Clearly, Star Trek was a little early in its predictions, but it's not difficult to imagine such a conflict happening in the future. Genetic modification was eventually banned except in cases of preventable problems (most genetic defects), though things like Geordi LaForge's blindness were unable to be cured. DS9 tackled what happens when people modify humans anyway, and how it can lead to a lower quality of life or unforseen side-effects, like sociopathy, aggressive behavior, uncontrollable libido, bipolar disorder, or even the inability to speak.
    As usual, it's all cautionary tales. Hopefully by the time we're at the super-soldier stage, humanity will be past the point of petty conflicts, and thus avoid a terrible war. And hopefully we'll be able to modify humans without harmful side-effects.

    • GLaDOnOS
      GLaDOnOS 5 days ago

      No, it is impossible to imagine that happening because shit doesn't pop out of no where in the real world. Everything evolves overtime. Everyone will be genetically modified by the time any big differences become noticeable. There will be no super soldiers either, because there are no freelunch's. There is always trade offs.

  • Raisa Khan
    Raisa Khan 6 days ago

    I want to be a genetic engineer

  • Ryan Mathis
    Ryan Mathis 6 days ago

    I wonder if natural selection will make us want “benefictial” genes or will it just shutdown completely.

  • Sunny Lee
    Sunny Lee 6 days ago

    It’s not a zebra fish it’s a zebra danio. Or Brachydanio rerio just saying politely :)

  • C. McMenemy
    C. McMenemy 6 days ago +1

    seeing those mice makes me think: how about a video about animal testing, then?

  • Gleb Firstov
    Gleb Firstov 6 days ago

    The race wars are gonna be pretty hardcore, just imagine, we've committed genocide over skin color and what god we believe in? You can bet there's gonna be a Civil War 2: Electric Boogaloo

    • Gleb Firstov
      Gleb Firstov 3 days ago

      @PvtMadnage - Bro. Matthew Alrighty there bucko

    • PvtMadnage - Bro. Matthew
      PvtMadnage - Bro. Matthew 3 days ago

      1 Timothy 2:5 (KJV)
      For there is one God, and one mediator between God and men, the man Christ Jesus;

  • Guinness
    Guinness 6 days ago +1

    So what you're saying here is that we are all fucked because we were born before CRISPR tech could help us.

  • rambobunny1
    rambobunny1 6 days ago

    hell no this is pure Nazi topia Nazi master race plan

  • Black Rose
    Black Rose 6 days ago

    In the future natural births will be considered disgusting, for poor people, and there will be natural birth racists because the children are worth less to them

  • Bleepboop
    Bleepboop 6 days ago

    "As soon as DNA was discovered, people tried to dick with it" XD
    I know you said tinker but it did sound a bit like dick and I find that really funny

  • A single Dorito
    A single Dorito 6 days ago

    I'm a Designer GUCCI baby

  • yonathan rakau
    yonathan rakau 6 days ago


  • infowolf1
    infowolf1 7 days ago +5

    its probably been done already. A POSSIBLE HISTORY OF LIFE ON MARS by Christine Erikson on amazon kindle.

  • just another account

    We can become immortal gods?? hell yeah

  • plmvirginiauva
    plmvirginiauva 7 days ago +1

    When genetic engineering is perfected and designer babies are possible then everyone will be white with blue or green eyes.

    • FBI
      FBI 5 days ago

      And have blonde hair, plus hate jews...

    • MarioWizard 119
      MarioWizard 119 6 days ago

      plmvirginiauva My designer baby would be unable to cry, shit, and be high in nutrients and taste just like chicken

  • North Korean Ministry of Propaganda and Buttercorn

    If they make Furrys able to grow tales imma blast bruh sound effect #2 whilst hunting them with a Barret .50

    • Jessica Hackett
      Jessica Hackett 2 days ago

      Therians are the ones who want to become animals. Furrys are people who dress up in a costume like cosplayers. Also, killing anyone because of a hobby is asinine in the extreme and threatening violence on anyone can land you in jail.

  • N.U.R an resolution
    N.U.R an resolution 7 days ago +1

    Im gonna do the captain america and more experiment on my to be the ultimate human predator of humanity and have fun to hunt down different human spicies that are not human sapien

  • Mash Rien
    Mash Rien 7 days ago +8

    I *was* alive in the 80s, and heard this through the mid-90s as well.
    Saying I'm old? ;-;

  • saboo
    saboo 7 days ago


  • King Nick
    King Nick 7 days ago +1

    Sounds cool

  • Mud Fox
    Mud Fox 7 days ago

    If we genetically modify ourselves in the future we could become like bnha world where we have superpowers and continue that way

    • GLaDOnOS
      GLaDOnOS 5 days ago

      Uhhhhhh Hahaha. No...

  • Jack Simmons
    Jack Simmons 7 days ago

    Les Enfants Terribles!

  • niki gacha stuff
    niki gacha stuff 7 days ago

    Lol tje future be like

    Robotik news:Selling a anime stile body
    Me:oooo i want that i have enough money
    Robotik new :only for ios robots if u want to be a ios robot u must pay 100000000000000000000000000000000000000000000000000000000000000000000000000000g

  • niki gacha stuff
    niki gacha stuff 7 days ago

    Oooo i wanna be a anime in the future one of thos where they have cat ears cat tail

  • a meme duck
    a meme duck 7 days ago +3

    so no one gonna mention adventure duck?